Skatole → N-methyl-7-azaindole

HRID 225907

Reaction equation

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[CH:3]=[CH:2]1.[CH3:10]C1C2C(=CC=CC=2)NC=1>>[CH3:10][N:1]1[C:9]2=[N:8][CH:7]=[CH:6][CH:5]=[C:4]2[CH:3]=[CH:2]1

Participants

Reactant 2

HCID 6736Skatole

HCID 92221H-Pyrrolo(2,3-b)pyridine

Product 1

HCID 583068N-methyl-7-azaindoleYield 58%

Procedure

According to the procedure of Preparation 40(a), except substituting 7-azaindole (2.28 g, 1.83 mmole) for the 3-methylindole, the title compound (1.4 g, 58%) was prepared as a yellow oil: MS (ES) m/e 133 (M+H)+.

Sources & evidence

ORD record: ord-91ad8c52c923465bb6c8f6d690e8f927
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557125B2

Linked notes

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