Acrylamide → 3-[{2-(1,3-Benzodioxol-5-yl)ethyl}thio]propionamide
Reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][SH:12])=[CH:9][C:4]=2[O:3][CH2:2]1.[C:13]([NH2:17])(=[O:16])[CH:14]=[CH2:15]>C(O)C>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][S:12][CH2:15][CH2:14][C:13]([NH2:17])=[O:16])=[CH:9][C:4]=2[O:3][CH2:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
5 g of 2-(1,3-benzodioxol-5-yl)ethanethiol and 4 g of acrylamide were dissolved in 100 ml of ethanol and the solution was heated under reflux to conduct the reaction for 20 h. The reaction mixture was cooled with ice. 100 ml of ethanol was added thereto and crystals thus formed were recovered by filtration to obtain 4.2 g of the intended compound in the form of colorless needles.
Workup
- temperaturethe solution was heated
- temperatureunder reflux
- customthe reaction for 20 h
- temperatureThe reaction mixture was cooled with ice
- customcrystals thus formed
- filtrationwere recovered by filtration
Sources & evidence
- ORD record
- ord-47aaf99627ea4e2093946d2b4eb65c62
- Source dataset
- uspto-grants-1995_12
- Patent number
- US05475024
Reaction notes
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