1H-Pyrazol-3-amine, 5-methyl- → HCID 178458053, compound
Reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][N:3]=1.[ClH:8].[C:9](=[NH:15])(OCC)[CH2:10][CH3:11]>C(#N)C>[ClH:8].[CH3:7][C:5]1[NH:4][N:3]=[C:2]([NH:1][C:9](=[NH:15])[CH2:10][CH3:11])[CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A 13.8 g portion of 3-amino-5-methyl-1H-pyrazole was dissolved in 52 ml of acetonitrile, and 22.0 g of ethyl propionimidate hydrochloride was added to the above solution with cooling on an ice bath. The resulting mixture was stirred for 1 hour at the same temperature and then overnight at room temperature.
Workup
- temperaturewith cooling on an ice bath
- customovernight
- customat room temperature
Sources & evidence
- ORD record
- ord-a04b8a2956f34528bf2a98b8cd87546e
- Source dataset
- uspto-grants-1995_12
- Patent number
- US05475114
Reaction notes
Loading…