Potassium Hydroxide → HCID 15825473, compound

HRID 2260092

Reaction equation

HRID 2260092 reaction equation
[OH:1][CH:2]([CH2:17][OH:18])[CH2:3][NH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[OH-].[K+].CO[C:23](=[O:40])[CH:24]([OH:39])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38]>>[OH:1][CH:2]([CH2:17][OH:18])[CH2:3][N:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:23](=[O:40])[CH:24]([OH:39])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38]

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 1024961,2-Propanediol, 3-(dodecylamino)-HCID 543716Methyl 2-hydroxyhexadecanoate

Product 1

HCID 15825473HCID 15825473, compound

Procedure

N-(2,3-dihydroxypropyl)-N-dodecylamine (1.00 g, 0.0039 mole) and potassium hydroxide (0.01 g, 0.18 mmole) were heated to 85° C. under vacuum and methyl-2-hydroxyhexadecanoate (1.12 g, 0.0039 mole) was heated and added dropwise to the reaction. The reaction was heated under vacuum for 6 hours. A waxy off-white solid was obtained (crude yield=1.9 g). The waxy solid was recrystalized from hot hexane (yield=1.26 g).

Workup

  1. temperaturewas heated
  2. additionadded dropwise to the reaction
  3. temperatureThe reaction was heated under vacuum for 6 hours
  4. customA waxy off-white solid was obtained (crude yield=1.9 g)
  5. customThe waxy solid was recrystalized from hot hexane (yield=1.26 g)

Sources & evidence

ORD record
ord-26d0ed40d8fa420097c96f1ceb2f5512
Source dataset
uspto-grants-1995_12
Patent number
US05476671

Linked notes

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