Thiazolidinedione → 5-{[4-(Dimethylamino)quinazolin-6-yl]methylidene}-1,3-thiazolidine-2,4-dione

HRID 2261124

Reaction equation

[CH3:1][N:2]([CH3:15])[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH:13]=O)[CH:11]=2)[N:6]=[CH:5][N:4]=1.[S:16]1[CH2:20][C:19](=[O:21])[NH:18][C:17]1=[O:22]>>[CH3:1][N:2]([CH3:15])[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH:13]=[C:20]3[S:16][C:17](=[O:22])[NH:18][C:19]3=[O:21])[CH:11]=2)[N:6]=[CH:5][N:4]=1

Participants

Reactant 2

HCID 5437Thiazolidinedione

HCID 574696434-(Dimethylamino)quinazoline-6-carbaldehyde2×

Product 1

HCID 713782605-{[4-(Dimethylamino)quinazolin-6-yl]methylidene}-1,3-thiazolidine-2,4-dione

Procedure

Following the general method as outlined in Example 1, starting from 4-Dimethylamino-quinazoline-6-carbaldehyde (intermediate 14) and 1,3-thiazolidine-2,4-dione, the title compound was obtained.

Sources & evidence

ORD record: ord-30dc8b29ef3b4fcfb01b0f34921f1098
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07846925B2

Linked notes

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