4-(Methylamino)quinazoline-6-carbaldehyde → 2-amino-5-[[4-(methylamino)quinazolin-6-yl]methylidene]-1,3-thiazol-4-one

HRID 2261128

Reaction equation

HRID 2261128 reaction equation
[CH3:1][NH:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH:13]=O)[CH:11]=2)[N:6]=[CH:5][N:4]=1.[NH:15]=[C:16]1[NH:20][C:19](=[O:21])[CH2:18][S:17]1>>[NH:15]=[C:16]1[NH:20][C:19](=[O:21])[C:18](=[CH:13][C:10]2[CH:11]=[C:12]3[C:7](=[CH:8][CH:9]=2)[N:6]=[CH:5][N:4]=[C:3]3[NH:2][CH3:1])[S:17]1

Participants

3

Reactant 2

HCID 574696384-(Methylamino)quinazoline-6-carbaldehyde2×HCID 1357419972-Aminothiazolinone HCl

Product 1

HCID 1784824082-amino-5-[[4-(methylamino)quinazolin-6-yl]methylidene]-1,3-thiazol-4-one

Procedure

Following the general method as outlined in Example 1, starting from 4-methylamino-quinazoline-6-carbaldehyde (intermediate 11) and 2-imino-1,3-thiazolidin-4-one, the title compound was obtained.

Sources & evidence

ORD record
ord-4077fd10c37b4bc88711bf249e6025f9
Source dataset
uspto-grants-2010_12
Patent number
US07846925B2

Linked notes

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