6-Bromo-3H-oxazolo(4,5-b)pyridin-2-one → 6-Bromo-3-(4-methylpiperidine-1-carbonyl)-3H-oxazolo[4,5-b]pyridin-2-one
Reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[O:10][C:9](=[O:11])[NH:8][C:5]2=[N:6][CH:7]=1.[CH3:12][CH:13]1[CH2:18][CH2:17][N:16]([C:19](Cl)=[O:20])[CH2:15][CH2:14]1>>[Br:1][C:2]1[CH:3]=[C:4]2[O:10][C:9](=[O:11])[N:8]([C:19]([N:16]3[CH2:17][CH2:18][CH:13]([CH3:12])[CH2:14][CH2:15]3)=[O:20])[C:5]2=[N:6][CH:7]=1Participants
3
Procedure
100 mg (0.46 mmol) of 6-bromo-3H-oxazolo[4,5-b]pyridin-2-one were reacted in analogy to Example 6 with 150 mg (0.93 mmol) of 4-methylpiperidin-1-carbonyl chloride. Yield: 78 mg (50%), M+H+: 340.09.
Sources & evidence
- ORD record
- ord-29d67c2a2f564be494c970cc0cf90373
- Source dataset
- uspto-grants-2010_12
- Patent number
- US07846943B2
Reaction notes
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