Thionyl Chloride → HCID 14674299, compound
Reaction equation
[C:1]([C:5]1[CH:9]=[C:8]([CH2:10]O)[O:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:14])=O>ClCCl>[C:1]([C:5]1[CH:9]=[C:8]([CH2:10][Cl:14])[O:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
1.12 g of (3-t-butyl-isoxazol-5-yl)methanol was dissolved in 35 ml of dichloromethane, and 2.4 ml of thionyl chloride was added. The mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure. The residue was washed with hexane to obtain 1.12 g of 3-t-butyl-5-(chloromethyl)-isoxazole.
Workup
- concentrationThe reaction mixture was concentrated under reduced pressure
- washThe residue was washed with hexane
Sources & evidence
- ORD record
- ord-356e4e5682644567a3388782d38711a5
- Source dataset
- uspto-grants-2010_12
- Patent number
- US07846956B2
Reaction notes
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