Thionyl Chloride → 1-Benzyl-4-(chloromethyl)-1H-pyrazole hydrochloride
Reaction equation
[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13]O)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>ClCCl>[ClH:17].[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][Cl:17])[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
1.88 g of (1-benzyl-1H-pyrazol-4-yl)methanol was dissolved in 30 ml of dichloromethane, and 2.1 ml of thionyl chloride was added. The mixture was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure to obtain 2.39 g of 1-benzyl-4-(chloromethyl)-1H-pyrazole hydrochloride.
Workup
- concentrationThe reaction mixture was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-4a99bdcd3ffa489d9110a75bc35c9670
- Source dataset
- uspto-grants-2010_12
- Patent number
- US07846956B2
Reaction notes
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