Thionyl Chloride → HCID 68776252, compound
Reaction equation
[C:1]([C:5]1[N:9]=[C:8]([CH2:10]O)[S:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:14])=O>ClCCl>[ClH:14].[C:1]([C:5]1[N:9]=[C:8]([CH2:10][Cl:14])[S:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
0.71 g of 3-t-butyl-5-hydroxymethyl-1,2,4-thiadiazole was dissolved in 20 ml of dichloromethane, and 1.4 ml of thionyl chloride was added. The mixture was stirred at room temperature for 4 hours. The reaction mixture was concentrated under reduced pressure to obtain 0.76 g of 3-t-butyl-5-(chloromethyl)-1,2,4-thiadiazole hydrochloride.
Workup
- concentrationThe reaction mixture was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-4456e86583b74c9d9e0d977db7cd52ad
- Source dataset
- uspto-grants-2010_12
- Patent number
- US07846956B2
Reaction notes
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