Phosgene → (2Z)-3-Amino-2-cyano-4-ethyl-2-hexenoyl chloride
Reaction equation
[C:1]([Cl:4])(Cl)=[O:2].[NH2:5][C:6]([CH:11]([CH2:14][CH3:15])[CH2:12][CH3:13])=[C:7]([C:9]#[N:10])C>C1(C)C=CC=CC=1>[NH2:5]/[C:6](/[CH:11]([CH2:14][CH3:15])[CH2:12][CH3:13])=[C:7](/[C:9]#[N:10])\[C:1]([Cl:4])=[O:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Procedure
250 ml toluene were cooled to 0° C. and 40 g (0.4 mol) of phosgene were added. After warming up to 25° C., 13.8 g (0.1 mol) of 3-amino-2-cyano-4-ethyl-2-hexene in toluene were added. The reaction mixture was heated at 70° C. for 4 h, then the unreacted phosgene was removed by blowing out with dry N2. After cooling to 25° C. the product precipitated. Filtration and washing with diethyl ether gave 12 g (60% of theory) of the title compound as a yellow solid (m. p. 102° C.).