Selenium → 7-Methoxy-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:16][CH2:15][C:10]3=[N:11][CH:12]=[CH:13][CH:14]=[C:9]3[C:8](=[O:17])[C:7]=2[CH:18]=1.[Se]>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH:16]=[CH:15][C:10]3=[N:11][CH:12]=[CH:13][CH:14]=[C:9]3[C:8](=[O:17])[C:7]=2[CH:18]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 120 °C
Procedure
A mixture of 2.3 g (9.6 mmol) of the product from Example 23 step 4, 1.85 g (16.6 mmol) of selenium dioxyde and 5 ml of pyridine is stirred at 120° C. for 6 hr. The whole is poured into excess petroleum ether and the solution is evaporated giving 0.55 g (24%) of enough pure title product as to prosecute with the synthesis.