epsilon-CAPROLACTONE → epsilon-Caprolactone p-Dioxanone

HRID 2263

Reaction equation

HRID 2263 reaction equation
[C:1]1(=[O:8])[O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[O:9]1[CH2:14][CH2:13][O:12][CH2:11][C:10]1=[O:15]>>[C:1]1(=[O:8])[O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[O:9]1[CH2:14][CH2:13][O:12][CH2:11][C:10]1=[O:15]

Participants

3

Reactant 2

HCID 10401epsilon-CAPROLACTONEHCID 18233Dioxanone

Product 1

HCID 86748302epsilon-Caprolactone p-Dioxanone

Procedure

The procedure in Example 5A is substantially repeated except that 45.7 grams (0.40 mole) of ε-caprolactone and 61.3 grams (0.60 mole) of p-dioxanone were used. The copolymer was dried under vacuum (0.1 mm Hg) at 80° C. for about 80 hours to remove any unreacted monomer. The copolymer had an inherent viscosity of 0.18 dL/g in HFIP at 25° C. The copolymer was a liquid at room temperature. The molar ratio of PCL/PDS was found to be 46.7/53.3 by proton NMR.

Workup

  1. customThe copolymer was dried under vacuum (0.1 mm Hg) at 80° C. for about 80 hours
  2. customto remove any unreacted monomer
  3. customat 25° C
  4. customat room temperature

Sources & evidence

ORD record
ord-38955b7c995840b4ae3dced0500d7938
Source dataset
uspto-grants-1998_03
Patent number
US05728752

Linked notes

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