Sodium Hydroxide → 1-[4-(4-Fluorophenyl)-2-thiazolyl]piperazine

HRID 2263188

Reaction equation

HRID 2263188 reaction equation
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[S:12][CH:13]=2)=[CH:5][CH:4]=1.[OH-].[Na+]>O>[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([N:14]3[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]3)[S:12][CH:13]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 687781261-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine hydrochloride

Product 1

HCID 80272011-[4-(4-Fluorophenyl)-2-thiazolyl]piperazineYield 89%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine hydrochloride (1.00 g, 2.97 mmol) was dissolved in water. The solution was neutralized with 1N aqueous sodium hydroxide solution, and the mixture was extracted with chloroform. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the desired product (696 mg, 67.2%) as an oil.

Workup

  1. extractionthe mixture was extracted with chloroform
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-1f68d41a50c640ff88e42ef17cbce328
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Linked notes

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