Ammonia → HCID 59595967, compound

Reaction equation

CO[C:3]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[C:5]([C:12]2[O:13][CH:14]=[CH:15][N:16]=2)[N:4]=1.[NH3:17]>>[N+:9]([C:8]1[C:3]([NH2:17])=[N:4][C:5]([C:12]2[O:13][CH:14]=[CH:15][N:16]=2)=[CH:6][CH:7]=1)([O-:11])=[O:10]

Participants

Reactant 2

HCID 222Ammonia

HCID 59595975HCID 59595975, compound

Product 1

HCID 59595967HCID 59595967, compoundYield 77%

Conditions

Temperature: 100 °C

Procedure

A suspension of 2-methoxy-3-nitro-6-(1,3-oxazol-2-yl)pyridine (0.187 g, 0.85 mmol) in aqueous ammonia (32%, 5 mL) was heated in a sealed tube to 100° C. with stirring. After 2.5 hours the mixture was cooled and the precipitate was filtered and washed with water and then dried in vacuo to give the title compound (0.134 g, 77%) as a yellow solid.

Workup

temperatureAfter 2.5 hours the mixture was cooled
filtrationthe precipitate was filtered
washwashed with water
customdried in vacuo

Sources & evidence

ORD record: ord-bade95ccfb0740ec8e7645ffadde844b
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07855202B2

Reaction notes

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