2,5-Bis(trifluoromethyl)aniline → HCID 57755030, compound

HRID 226542

Reaction equation

HRID 226542 reaction equation
[CH3:1][O:2][C:3](=[O:34])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([F:29])[CH:26]=[C:25]([C:30]([F:33])([F:32])[F:31])[CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:35][C:36]([F:49])([F:48])[C:37]1[CH:43]=[CH:42][C:41]([C:44]([F:47])([F:46])[F:45])=[CH:40][C:38]=1[NH2:39]>>[CH3:1][O:2][C:3](=[O:34])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([F:29])[CH:26]=[C:25]([C:30]([F:32])([F:33])[F:31])[CH:24]=2)[CH:12]=[C:13]([NH:39][C:38]2[CH:40]=[C:41]([C:44]([F:45])([F:46])[F:47])[CH:42]=[CH:43][C:37]=2[C:36]([F:35])([F:48])[F:49])[CH:14]=1)[CH2:5][CH:6]([CH3:7])[CH3:8]

Participants

3

Reactant 2

HCID 7198182,5-Bis(trifluoromethyl)anilineHCID 577549252-(3'-Fluoro-5-trifluoromethanesulfonyloxy-5'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester

Product 1

HCID 57755030HCID 57755030, compoundYield 100%

Procedure

The title compound was prepared in 100% yield from 2-(5′-fluoro-5-trifluoromethanesulfonyloxy-3′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester and 2,5-bis-(trifluoromethyl)aniline under the conditions described in Example 37, step (b).

Sources & evidence

ORD record
ord-330a8005533c45cebbcc8911042eeee8
Source dataset
uspto-grants-2009_07
Patent number
US07557244B2

Linked notes

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