4-Fluoro-2-(trifluoromethyl)aniline → HCID 57755026, compound

HRID 226543

Reaction equation

HRID 226543 reaction equation
[CH3:1][O:2][C:3](=[O:34])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:26]=[C:25]([F:33])[CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:35][C:36]1[CH:42]=[CH:41][C:39]([NH2:40])=[C:38]([C:43]([F:46])([F:45])[F:44])[CH:37]=1>>[CH3:1][O:2][C:3](=[O:34])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:24]=[C:25]([F:33])[CH:26]=[C:27]([C:29]([F:30])([F:32])[F:31])[CH:28]=2)[CH:12]=[C:13]([NH:40][C:39]2[CH:41]=[CH:42][C:36]([F:35])=[CH:37][C:38]=2[C:43]([F:46])([F:44])[F:45])[CH:14]=1)[CH2:5][CH:6]([CH3:7])[CH3:8]

Participants

3

Reactant 2

HCID 678534-Fluoro-2-(trifluoromethyl)anilineHCID 57754925HCID 57754925, compound

Product 1

HCID 57755026HCID 57755026, compoundYield 100%

Procedure

The title compound was prepared in 100% yield from 2-(5′-fluoro-5-trifluoromethanesulfonyloxy-3′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester (prepared in Example 40, step (a)) and 4-fluoro-2-(trifluoromethyl)aniline under the conditions described in Example 37, step (b).

Sources & evidence

ORD record
ord-b8eaff4f78d04a6da7323556b979dad8
Source dataset
uspto-grants-2009_07
Patent number
US07557244B2

Linked notes

Loading…