Phenol, 4-methoxy-2-nitro- → 2-Amino-4-methoxyphenol
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[C:5]([N+:10]([O-])=O)[CH:4]=1>CO.[Pd]>[NH2:10][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=1[OH:9]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 4-methoxy-2-nitrophenol 11 (10 g, 59.1 mmol) and Pd/C (1.0 g) in methanol (100 ml) was placed on a Parr shaker under H2 (50 psi) for 60 minutes. The reaction mixture was filtered through Celite 521 and the filter cake washed with MeOH. The filtrate was evaporated (in vacuo), to yield compound 12 as a tan solid.
Workup
- filtrationThe reaction mixture was filtered through Celite 521
- washthe filter cake washed with MeOH
- customThe filtrate was evaporated (in vacuo)
Sources & evidence
- ORD record
- ord-4d5d8283e50c4141aca07510c1511933
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06849632B2
Reaction notes
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