3-(4-Nitrobenzyl)imidazolidine-2,4-dione → 3-[(4-Aminophenyl)methyl]imidazolidine-2,4-dione
Reaction equation
[N+:1]([C:4]1[CH:17]=[CH:16][C:7]([CH2:8][N:9]2[C:13](=[O:14])[CH2:12][NH:11][C:10]2=[O:15])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd].[H][H]>[NH2:1][C:4]1[CH:17]=[CH:16][C:7]([CH2:8][N:9]2[C:13](=[O:14])[CH2:12][NH:11][C:10]2=[O:15])=[CH:6][CH:5]=1Participants
5
Procedure
The 3-(4-nitrobenzyl)hydantoin derivative as dissolved in methanol (about 10 ml per mmol of hydantoin derivative) and hydrogenated with palladium/carbon in a hydrogen atmosphere until reaction was complete. The catalyst was filtered off and the solvent was removed on a rotary evaporator. The 3-(4-aminobenzyl)hydantoin derivative was obtained.
Workup
- filtrationThe catalyst was filtered off
- customthe solvent was removed on a rotary evaporator
Sources & evidence
- ORD record
- ord-c31f846a3aad43c1a475eae085db9853
- Source dataset
- uspto-grants-2001_12
- Patent number
- US06331552B1
Reaction notes
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