HCID 22632884, compound → HCID 9820196, compound
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:23])=[C:15]([N:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[CH:16]=3)[C:11](=[O:24])[N:10]([O:25]CC3C=CC=CC=3)[C:9]2=[O:33])=[CH:4][CH:3]=1>[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:23])=[C:15]([N:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[CH:16]=3)[C:11](=[O:24])[N:10]([OH:25])[C:9]2=[O:33])=[CH:4][CH:3]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Using the General Method 6A, the reaction of 10% Pd/C (0.027 g) with 1-(4-fluorophenyl)-6-fluoro-3-benzyloxy-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione (Example L-1, 0.08 g, 0.18 mmol) afforded 0.05 g of the title compound as a solid, mp 183-185° C.
Sources & evidence
- ORD record
- ord-d1f88ea64cb24cc99b3d5fbf1ea71311
- Source dataset
- uspto-grants-2001_12