Benzoxazole → 4-(Oxiran-2-ylmethoxy)quinoline

HRID 22717

Reaction equation

[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[O:12]1[C:16]2[CH:17]=[CH:18]C=CC=2N=C1>>[O:12]1[CH2:16][CH:17]1[CH2:18][O:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 9228Benzoxazole

HCID 178516385quinolin-4-ol

Product 1

HCID 218922824-(Oxiran-2-ylmethoxy)quinoline

Procedure

Compound 75 was prepared in the manner of compound 6 substituting 4-hydroxy-quinoline for compound 8 in part C-5 of Example 1.

Sources & evidence

ORD record: ord-c11a7cd56a684bd282736cf3717b6d48
Source dataset: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06849632B2

Linked notes

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