3-(3,4-dichlorophenyl)-N-methoxy-N-methylpropanamide → 4-(3,4-Dichlorophenyl)butan-2-one
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11](N(OC)C)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:17][Mg]Br>CCOCC>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11](=[O:12])[CH3:17])[CH:5]=[CH:6][C:7]=1[Cl:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
At 0° C. to a solution of 3-(3,4-dichlorophenyl)-N-methoxy-N-methylpropanamide (569 mg, 2.17 mmol) in ether (10 mL) was added drop wise methyl magnesium bromide (2.17 mL, 6.51 mmol) and the solution was stirred at 0° C. for 1 h. The reaction mixture was allowed to warm up to rt and stirred for 18 h.
Workup
- temperatureto warm up to rt
- stirringstirred for 18 h.
Sources & evidence
- ORD record
- ord-d22288dc80f54ce58190125990416f3b
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09120794B2
Reaction notes
Loading…