Sulfuric Acid → Sulfuric acid--17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol--water (1/1/5)

HRID 2275054Notes

Reaction equation

[CH:1]1[C:17]2[CH2:16][C@H:15]3[N:18]([CH2:20][CH2:21][C@@:7]45[C@H:14]3[CH:13]=[CH:12][C@H:10]([OH:11])[C@@H:8]4[O:9][C:5]([C:6]=25)=[C:3]([OH:4])[CH:2]=1)[CH3:19].[S:22](=[O:26])(=[O:25])([OH:24])[OH:23]>O>[OH2:4].[OH2:23].[OH2:4].[OH2:4].[OH2:4].[S:22]([OH:26])([OH:25])(=[O:24])=[O:23].[CH:1]1[C:17]2[CH2:16][C@H:15]3[N:18]([CH2:20][CH2:21][C@@:7]45[C@H:14]3[CH:13]=[CH:12][C@H:10]([OH:11])[C@@H:8]4[O:9][C:5]([C:6]=25)=[C:3]([OH:4])[CH:2]=1)[CH3:19]

Participants

Conditions

Temperature: 55 °C

Procedure

Morphine free base material (AMA) from Example 4 (19 ppm ABUK) and water were mixed, heated to 55° C. and the pH was determined to be 7.75. The following titration was performed using sulfuric acid (51%) as the temperature was increased to about 65° C.

Workup

temperaturewas increased to about 65° C.

Sources & evidence

ORD record: ord-546fd9b6370b43e98550814ee2821798
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09127008B2

Reaction notes

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