Methyl acetoacetate → HCID 70981314, compound
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5](Cl)=[N:6][OH:7].[CH3:12][O:13][C:14](=[O:19])[CH2:15][C:16]([CH3:18])=O.C[O-].[Na+]>CO>[CH3:12][O:13][C:14]([C:15]1[C:5]([C:4]2[CH:9]=[CH:10][CH:11]=[C:2]([F:1])[CH:3]=2)=[N:6][O:7][C:16]=1[CH3:18])=[O:19]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
In a similar manner as described in Preparation Example 17, by using methanol (160 mL), 3-fluoro-N-hydroxybenzimidoyl chloride (8.00 g, 46.09 mmol), methylacetoacetate (10.07 g, 92.18 mmol) and sodium methoxide (7.47 g, 138.27 mmol), a white solid required compound (7.60 g, 32.14 mmol, 70%) was obtained.
Workup
- customIn a similar manner as described in Preparation Example 17
Sources & evidence
- ORD record
- ord-e35d00a10a5c434a9794cb428a4268c0
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09132126B2
Reaction notes
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