Methyl cyanoacetate → HCID 70981046, compound
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5](Cl)=[N:6][OH:7].[CH3:12][O:13][C:14](=[O:18])[CH2:15][C:16]#[N:17].C[O-].[Na+]>CO>[NH2:17][C:16]1[O:7][N:6]=[C:5]([C:4]2[CH:9]=[CH:10][CH:11]=[C:2]([F:1])[CH:3]=2)[C:15]=1[C:14]([O:13][CH3:12])=[O:18]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
In a similar manner as described in Preparation Example 17, by using methanol (160 mL), 3-fluoro-N-hydroxybenzimidoyl chloride (8.00 g, 46.09 mmol), methylcyanoacetate (5.94 g, 59.92 mmol) and sodium methoxide (4.98 g, 92.18 mmol), a white solid required compound (8.42 g, 35.64 mmol, 77%) was obtained.
Workup
- customIn a similar manner as described in Preparation Example 17
Sources & evidence
- ORD record
- ord-b28099628e544dab958755b74c94edd8
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09132126B2
Reaction notes
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