Water → HCID 57755833, compound

HRID 227695

Reaction equation

[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[C:7]2[NH2:13])([O-:3])=[O:2].[C:14](OC(=O)C)(=[O:16])[CH3:15].[OH2:21].N1[CH:27]=[CH:26]C=CC=1>>[C:14]([N:9]1[C:10]2[C:6](=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:12][CH:11]=2)[C:7]([NH:13][C:26](=[O:21])[CH3:27])=[N:8]1)(=[O:16])[CH3:15]

Participants

Reactant 4

HCID 962Water

HCID 1049Pyridine

HCID 7918Acetic Anhydride

HCID 31366553-Amino-5-nitroindazole

Product 1

HCID 57755833HCID 57755833, compoundYield 91%

Procedure

The product from Step (a) above (3.6 g, 20.2 mmol) was dissolved in pyridine (30 mL), acetic anhydride (4.15 mL, 44 mmol) was added and the mixture was stirred overnight at rt. The red solution was pouted into H2O and the resulting solid was filtered to give the title compunt as a red solid (4.8 g, 91%). NMR 1H NMR (400 MHz, DMSO-D6) δ 11.21 (br s, 1H), 9.08 (s, 1H), 8.46 (s, 2H), 2.51 (s, 3H), 2.23 (s, 3H) (MS m/z 263.2.0 [M+H]+

Workup

filtrationthe resulting solid was filtered

Sources & evidence

ORD record: ord-1a43f481a3d64d9fbdc7114267fb6e72
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07560467B2

Linked notes

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