4-(1-(Hydroxymethyl)cyclopropyl)phenylboronic acid → HCID 90407600, compound
Reaction equation
Br[C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]1[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=1.[OH:16][CH2:17][C:18]1([C:21]2[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=2)[CH2:20][CH2:19]1>>[OH:16][CH2:17][C:18]1([C:21]2[CH:26]=[CH:25][C:24]([C:2]3[N:6]([CH3:7])[CH:5]=[N:4][C:3]=3[C:8]3[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=3)=[CH:23][CH:22]=2)[CH2:20][CH2:19]1Participants
3
Procedure
The title compound was prepared from 2-(5-bromo-1-methyl-1H-imidazol-4-yl)pyridine-4-carbonitrile and 4-(1-(hydroxymethyl)cyclopropyl)phenylboronic acid according to the procedure for the preparation of Example 3, part A. [M+H] Calc'd for C20H18N4O, 331. Found, 331.
Sources & evidence
- ORD record
- ord-8f6b66293d154dc4acb58a09e52236a0
- Source dataset
- uspto-grants-2015_09