Benzaldehyde → 4-tert-butyl-N-[6-{2-(5-(alpha-hydroxybenzyl)primidin-2-yloxy)ethoxy}-5-(4-methylphenyl)pyrimidin-4-yl]-benzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	Benzaldehyde	HCID 240	—
Reactant	4-tert-butyl-N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(4-methylphenyl)pyrimidin-4-yl}benzenesulfonamide	HCID 9938571	—
Product	4-tert-butyl-N-[6-{2-(5-(alpha-hydroxybenzyl)primidin-2-yloxy)ethoxy}-5-(4-methylphenyl)pyrimidin-4-yl]-benzenesulfonamide	HCID 131719757	—

Reaction Steps

N-[6-{2-(5-Bromopyrimidin-2-yloxy)ethoxy}-5-(4-methylphenyl)pyrimidin-4-yl]-4-tert-butylbenzenesulfonamide and benzaldehyde are treated in the same manner as in Example 129 to give 4-tert-butyl-N-[6-{2-(5-(α-hydroxybenzyl)primidin-2-yloxy)ethoxy}-5-(4-methylphenyl)pyrimidin-4-yl]-benzenesulfonamide.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05728706
Source dataset	uspto-grants-1998_03
ORD ID	ord-8cd0277d133e4a558c95fad0e057819e
Source note	uspto-grants-1998_03