2-Methyl-2H-pyrazol-3-ylamine → N-(2-ethoxypyridin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-amine

Reaction equation

[CH3:1][N:2]1[C:6](N)=[CH:5][CH:4]=[N:3]1.[CH2:8]([O:10][C:11]1[CH:16]=[C:15]([NH2:17])[CH:14]=[CH:13][N:12]=1)[CH3:9]>>[CH2:8]([O:10][C:11]1[CH:16]=[C:15]([NH:17][C:1]2[N:3]=[CH:4][C:5]3[CH2:5][CH2:6][NH:2][CH2:1][C:6]=3[N:2]=2)[CH:14]=[CH:13][N:12]=1)[CH3:9]

Participants

Reactant 2

HCID 1369272-Methyl-2H-pyrazol-3-ylamine

HCID 27629614-Amino-2-ethoxypyridine

Product 1

HCID 68294219N-(2-ethoxypyridin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-amine

Procedure

N-(2-ethoxypyridin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-amine (186) was prepared in accord with the procedures described in steps 1 to 4 of example 25 except in step 1, 1-methyl-1H-pyrazol-5-amine was replaced with 2-ethoxypyridin-4-amine.

Sources & evidence

ORD record: ord-0f8aeb369d8a43eebf03dfcae56e1867
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09133187B2

Reaction notes

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