1,2,3,6-Tetrahydropyridine → HCID 23121981, compound

Reaction equation

[NH:1]1[CH2:6][CH:5]=[CH:4][CH2:3][CH2:2]1.N[CH2:8][C@@H:9]1CC[CH2:11][N:10]1CC>>[N:1]1([CH2:8][CH2:9][NH:10][CH3:11])[CH2:2][CH:3]=[CH:4][CH2:5][CH2:6]1

Participants

Reactant 2

HCID 127501,2,3,6-Tetrahydropyridine

HCID 643457(S)-(-)-2-Aminomethyl-1-ethylpyrrolidine

Product 1

HCID 23121981HCID 23121981, compound

Procedure

By using 1,2,3,6-tetrahydropyridine (960.2 mg) as a starting material, the title compound (855 mg) was obtained in the same manners as those of Reference Example 1, (1) and Reference Example 19, (3).

Sources & evidence

ORD record: ord-7dcfd6418cc9454e8955c3aafd146859
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09139609B2

Reaction notes

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