Water → 3-[Ethyl(hydroxy)phosphoryl]propanoic acid
Reaction equation
[CH2:1]([P:3]([O:10]CCCC)([CH2:5][CH2:6][C:7]([OH:9])=[O:8])=[O:4])[CH3:2].O>C(O)CCC.O>[CH2:1]([P:3]([OH:10])([CH2:5][CH2:6][C:7]([OH:9])=[O:8])=[O:4])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
444 g (2 mol) of 3-(ethylbutoxyphosphinyl)propionic acid (produced as in Example 13) are initially charged in a 1 l five-neck flask equipped with thermometer, reflux condenser, high-performance stirrer and dropping funnel. At 160° C., during 4 h, 500 ml of water are metered in and a butanol-water mixture is distilled off. The solid residue is recrystallized from acetone to obtain 309 g (93% of theory) of 3-(ethylhydroxyphosphinyl)propionic acid as colorless solid.
Workup
- customequipped with thermometer
- temperaturereflux condenser, high-performance stirrer
- distillationis distilled off
- customThe solid residue is recrystallized from acetone
Sources & evidence
- ORD record
- ord-8303d39327b64bdeb30169c916034bb8
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09139714B2
Reaction notes
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