3,3-Dimethyl-1-butyne → HCID 57750924, compound

Reaction equation

Br[C:2]1[CH:3]=[C:4]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[S:18](=[O:21])(=[O:20])[NH2:19])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH3:22][C:23]([CH3:27])([CH3:26])[C:24]#[CH:25]>>[CH3:22][C:23]([CH3:27])([CH3:26])[C:24]#[C:25][C:2]1[CH:3]=[C:4]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[S:18](=[O:21])(=[O:20])[NH2:19])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 135123,3-Dimethyl-1-butyne

HCID 57751032HCID 57751032, compound

Product 1

HCID 57750924HCID 57750924, compoundYield 27%

Procedure

The title compound was synthesized as described for Example 179a) in 27% yield, starting from 3-bromo-N-(2-sulfamoylphenyl)benzenesulfonamide and 3,3-dimethyl-1-butyne.

Sources & evidence

ORD record: ord-a0fa3c5fdb1b43a088eeeedd6542d8ff
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09145380B2

Reaction notes

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