(E)-2-(4-chlorophenyl)ethene-1-sulfonyl chloride → (E)-5-Chloro-2-(2-(4-chlorophenyl)vinylsulfonamido)-4-fluorobenzene sulfonamide
Reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([Cl:9])=[CH:4][C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].[Cl:14][C:15]1[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[S:23](Cl)(=[O:25])=[O:24])=[CH:17][CH:16]=1>>[Cl:9][C:5]1[C:6]([F:8])=[CH:7][C:2]([NH:1][S:23](/[CH:22]=[CH:21]/[C:18]2[CH:19]=[CH:20][C:15]([Cl:14])=[CH:16][CH:17]=2)(=[O:24])=[O:25])=[C:3]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:4]=1Participants
3
Procedure
The title compound was synthesized as described for 226 a) in 61% yield, starting from 2-amino-5-chloro-4-fluorobenzenesulfonamide and (E)-2-(4-chlorophenyl)ethenesulfonyl chloride.
Sources & evidence
- ORD record
- ord-2485d03d1a3e40a0876fb68bf4269a8b
- Source dataset
- uspto-grants-2015_09