(E)-2-(3,4-dichlorophenyl)ethenesulfonyl chloride → (E)-5-Chloro-2-(2-(3,4-dichlorophenyl)vinylsulfonamido)-4-fluoro benzenesulfonamide
Reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([Cl:9])=[CH:4][C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].[Cl:14][C:15]1[CH:16]=[C:17](/[CH:22]=[CH:23]/[S:24](Cl)(=[O:26])=[O:25])[CH:18]=[CH:19][C:20]=1[Cl:21]>>[Cl:9][C:5]1[C:6]([F:8])=[CH:7][C:2]([NH:1][S:24](/[CH:23]=[CH:22]/[C:17]2[CH:18]=[CH:19][C:20]([Cl:21])=[C:15]([Cl:14])[CH:16]=2)(=[O:26])=[O:25])=[C:3]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:4]=1Participants
3
Procedure
The title compound was synthesized as described for Example 226 a) in 40% yield, starting from 2-amino-5-chloro-4-fluorobenzenesulfonamide and (E)-2-(3,4-dichlorophenyl)ethenesulfonyl chloride.
Sources & evidence
- ORD record
- ord-92a7f699cf22425ea2961bb2572a91ca
- Source dataset
- uspto-grants-2015_09