4-(4-Hydroxy-1-piperidinyl)benzoic acid → HCID 67112745, compound

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:21]=[CH:20][C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][CH:12]=1)[N:6]=[CH:5]2.[OH:22][CH:23]1[CH2:28][CH2:27][N:26]([C:29]2[CH:37]=[CH:36][C:32]([C:33](O)=[O:34])=[CH:31][CH:30]=2)[CH2:25][CH2:24]1>>[OH:22][CH:23]1[CH2:24][CH2:25][N:26]([C:29]2[CH:37]=[CH:36][C:32]([C:33]([NH:1][C:2]3[CH:3]=[C:4]4[C:8](=[CH:9][CH:10]=3)[N:7]([C:11]3[CH:12]=[CH:13][C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:20][CH:21]=3)[N:6]=[CH:5]4)=[O:34])=[CH:31][CH:30]=2)[CH2:27][CH2:28]1

Participants

Reactant 2

HCID 186175914-(4-Hydroxy-1-piperidinyl)benzoic acid

HCID 67112963HCID 67112963, compound

Product 1

HCID 67112745HCID 67112745, compound

Procedure

Compound 1030 was prepared according to the procedure described in Scheme IV from ethyl 4-(5-amino-1H-indazol-1-yl)benzoate and 4-(4-hydroxypiperidin-1-yl)benzoic acid. [M+H]+ calcd for C28H28N4O4: 485.21; found: 485.09.

Sources & evidence

ORD record: ord-a28c6e3714ce4bfaa478647b0a451157
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09144557B2

Reaction notes

Loading…