Hydrochloride methanol → 6,7-Dimethoxy-4-(3,4-dimethylphenoxy)quinoline hydrochloride
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[C:18]([CH3:23])[CH:17]=1.[ClH:24].CO>>[ClH:24].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[C:18]([CH3:23])[CH:17]=1Participants
3
Procedure
6,7-Dimethoxy-4-(3,4-dimethylphenoxy)quinoline (122 mg) was dissolved in a 10% hydrochloric acid/methanol solution, and the solution was stirred at room temperature for 15 min. The solvent was removed therefrom by distillation under the reduced pressure. The residue was washed with ethyl acetate to give the title compound (118 mg, yield 87%).
Workup
- customThe solvent was removed
- distillationby distillation under the reduced pressure
- wash