5-(Hydroxymethyl)pyrrolidin-2-one → 6-Oxo-piperidine-2-carbaldehyde
Reaction equation
[OH:1][CH2:2][CH:3]1[NH:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4]1.OCC1NC(=O)CC1>>[CH:2]([CH:3]1[NH:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4]1)=[O:1]Participants
3
Procedure
When in the procedure of Example 6 (A) an appropriate amount of 6-hydroxymethyl-2-piperidone is substituted for 5-hydroxymethyl-2-pyrrolidone, 6-formyl-2-piperidone is obtained. When an appropriate amount of 6-formyl-2-piperidone is substituted for 5-formyl-2-pyrrolidone in the procedure of Example 6 (B), 6-difluoromethyl-2-piperidone is obtained which, when substituted for 5-difluoromethyl-2-pyrrolidone in an appropriate amount in the procedure of Example 5, yields 5-amino-5-difluoromethylpentanoic acid.
Sources & evidence
- ORD record
- ord-fd32177042dd40cb93dfc3c6295309c8
- Source dataset
- uspto-grants-1982_04
- Patent number
- US04326071
Reaction notes
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