HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 228643Generated: October 23, 2026
2-Iodo-6-methylpyridin-3-ol → 4-[(6-Methyl-3-pyridyl)oxy]-6,7-dimethoxyquinoline
https://huagongshe.com/en/reaction/228643
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Iodo-6-methylpyridin-3-ol | HCID 89957 | — |
| Reactant | 4-Chloro-6,7-dimethoxyquinoline | HCID 459610 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | 1,2-Dichlorobenzene | HCID 7239 | — |
| Product | 4-[(6-Methyl-3-pyridyl)oxy]-6,7-dimethoxyquinoline | HCID 23156628 | 61.3% |
Reaction Steps
4-Chloro-6,7-dimethoxyquinoline (229 mg), 3-hydroxy-2-iodo-6-methylpyridine (486 mg), and 4-dimethylaminopyridine (390 mg) were suspended in o-dichlorobenzene (5 ml), and the suspension was stirred at 140° C. overnight. The reaction solution was cooled to room temperature and was then purified by column chromatography using acetone-chloroform to give the title compound (186 mg, yield 61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07560558B2 |
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| Source dataset | uspto-grants-2009_07 |
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| ORD ID | ord-34b0655ea6c04a9ea66bcd791d15dedf |
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| Source note | uspto-grants-2009_07 |
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