Acetic Acid → N-(3-formyl-2-methylphenyl)acetamide
Reaction equation
[CH3:1][C:2]1[C:9]([NH2:10])=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#N.[C:11](OC(=O)C)(=[O:13])[CH3:12].C(O)(=[O:20])C>>[CH3:1][C:2]1[C:9]([NH:10][C:11](=[O:13])[CH3:12])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:20]Participants
4
Procedure
39g (0.3 mole) of 2-methyl-3-amino-benzonitrile were dissolved in 75 ml of acetic acid, 30 ml (0.3 mole) of acetic anhydride were added, the mixture was heated with reflux for 5 minutes, and cooled. The solid obtained was filtered off and the evaporation of the solent furnished an additional quantity of solid which was added to the preceding one. After recrystallisation of the whole from toluene, 44 g (95%) of colorless flakes were obtained, with a melting point of 160° C. l
Workup
- temperaturethe mixture was heated
- temperaturewith reflux for 5 minutes
- temperaturecooled
- customThe solid obtained
- filtrationwas filtered off
- customthe evaporation of the
- customsolent furnished an additional quantity of solid which
- additionwas added to the preceding one
- customAfter recrystallisation of the whole from toluene, 44 g (95%) of colorless flakes
- customwere obtained, with a melting point of 160° C. l
Sources & evidence
- ORD record
- ord-4e54882d31324ec0ac58cc74ee3f731a
- Source dataset
- uspto-grants-1981_05
- Patent number
- US04266060
Reaction notes
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