(4,5-Dimethylfuran-2-yl)-(4,5-dimethylthiazol-2-yl)methanol → (4,5-Dimethylfuran-2-yl)(4,5-dimethylthiazol-2-yl)-methanone

HRID 228796

Reaction equation

HRID 228796 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]([C:10]2[S:11][C:12]([CH3:16])=[C:13]([CH3:15])[N:14]=2)[OH:9])[O:5][C:6]=1[CH3:7]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[S:11][C:12]([CH3:16])=[C:13]([CH3:15])[N:14]=2)=[O:9])[O:5][C:6]=1[CH3:7]

Participants

4

Reactant 1

HCID 23078354(4,5-Dimethylfuran-2-yl)-(4,5-dimethylthiazol-2-yl)methanol

Product 1

HCID 23078247(4,5-Dimethylfuran-2-yl)(4,5-dimethylthiazol-2-yl)-methanoneYield 97.1%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

(4,5-Dimethylfuran-2-yl)-(4,5-dimethylthiazol-2-yl)methanol (945 mg) was dissolved in chloroform (20 ml) to prepare a solution. Manganese dioxide (3.5 g) was added to the solution, and the mixture was stirred at room temperature overnight. The reaction solution was filtered through Celite, and the solvent was removed from the filtrate by distillation under the reduced pressure to give (4,5-dimethylfuran-2-yl)(4,5-dimethylthiazol-2-yl)-methanone (910 mg, yield 97%).

Workup

  1. customto prepare a solution
  2. filtrationThe reaction solution was filtered through Celite
  3. customthe solvent was removed from the filtrate by distillation under the reduced pressure

Sources & evidence

ORD record
ord-ff9c0126c13c495080a3055c9946dee9
Source dataset
uspto-grants-2009_07
Patent number
US07560558B2

Linked notes

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