Pyrimidine → HCID 54493243, compound

HRID 2289368

Reaction equation

HRID 2289368 reaction equation
[CH3:1][C@@H:2]([CH2:6][CH3:7])[CH2:3][CH2:4][OH:5].N1C=CC=NC=1.[CH3:14][S:15](Cl)(=[O:17])=[O:16]>>[CH3:14][S:15]([O:5][CH2:4][CH2:3][C@@H:2]([CH3:1])[CH2:6][CH3:7])(=[O:17])=[O:16]

Participants

4

Reactant 3

HCID 9260PyrimidineHCID 31297Methanesulfonyl chlorideHCID 641003(S)-(+)-3-Methyl-1-pentanol

Product 1

HCID 54493243HCID 54493243, compoundYield 46.42%

Procedure

In a flask were charged 15.89 g of (S)-3-methylpentanol and 65 ml of pyrimidine. After cooling to 0° to 50° C., 23.63 g of methanesulfonyl chloride was added thereto dropwise, and the mixture was allowed to react at the same temperature for 1 hour. The reaction mixture was extracted with diethyl ether, and the extract was washed with water and concentrated to obtain 12.14 g (46.42%) of the titled compound.

Workup

  1. temperatureAfter cooling to 0° to 50° C.
  2. customto react at the same temperature for 1 hour
  3. extractionThe reaction mixture was extracted with diethyl ether
  4. washthe extract was washed with water
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-5da116c9920b45c5b94894bd56232f10
Source dataset
uspto-grants-2000_07
Patent number
US06093345

Linked notes

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