Sodium borohydride → 3-(2-Acetylhydrazino)-5-methyl-6-phenyl-2,5-dihydro-1,2,4-triazine
Reaction equation
[BH4-].[Na+].[C:3]([NH:6][NH:7][C:8]1[N:9]=[N:10][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:12]([CH3:14])[N:13]=1)(=[O:5])[CH3:4]>CO>[C:3]([NH:6][NH:7][C:8]1[NH:9][N:10]=[C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:12]([CH3:14])[N:13]=1)(=[O:5])[CH3:4]Participants
4
Procedure
Sodium borohydride (1.11 g) was added to a stirred solution of 3-(2-acetylhydrazino)-5-methyl-6-phenyl-1,2,4-triazine (3.29 g) in methanol (30 ml) at room temperature and then the stirring was continued for 1 hour. The precipitates were collected by filtration, washed successively with water, methanol, and diisopropyl ether, and then recrystallized from a mixture of methanol and water to give colorless crystals of 3-(2-acetylhydrazino)-5-methyl-6-phenyl-2,5-dihydro-1,2,4-triazine (1.39 g), m.p. 204.5°~205° C. (decomp.).