Cyclopropyl(3-nitrophenyl)methanone → (3-Aminophenyl)(cyclopropyl)methanone
Reaction equation
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[CH:7]=2)=[O:5])[CH2:3][CH2:2]1.[H][H]>[Pd].CO>[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([NH2:12])[CH:7]=2)=[O:5])[CH2:2][CH2:3]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A Parr hydrogenation tube is charged with palladium on carbon (0.030 g). cyclopropyl-(3-nitrophenyl)methanone of Preparation 45 (0.250 g) and 10 mL of methanol. The tube is shaken at room temperature under 40 psi of hydrogen overnight. The reaction mixture is then filtered through Celite and concentrated to give 0.207 g of the title product which is used without further purification.
Workup
- filtrationThe reaction mixture is then filtered through Celite
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-306fdae43ae840b48afe80ec6a50af2d
- Source dataset
- uspto-grants-1997_11
- Patent number
- US05686486
Reaction notes
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