3-Amino-2-chloro-4-methylpyridine → 2-Chloro-4-phenylpyridin-3-amine
Reaction equation
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[CH:6][C:7]=1[CH3:8]>C(Cl)Cl>[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
adjusting the pH of the aqueous phase to between 3.5 and 5 by the addition of a base, and isolating the 3-amino-2-chloro-4-methyl-pyridine so produced by extraction into methylene chloride, followed by evaporation of the methylene chloride.
Workup
- additionby the addition of a base
- customfollowed by evaporation of the methylene chloride
Sources & evidence
- ORD record
- ord-65a470b35fd84179ae210ee8a55d130f
- Source dataset
- uspto-grants-1997_11
- Patent number
- US05686618
Reaction notes
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