HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 229439Generated: October 26, 2026
Diisopropylethylamine → Diethyl 5-(4-fluorophenyl)-2-furanphosphonate
https://huagongshe.com/reaction/229439
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | Diethyl 5-iodo-2-furanphosphonate | HCID 22280644 | — |
| Catalyst | Bis(acetonitrile)dichloropalladium | HCID 6093782 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Diethyl 5-(4-fluorophenyl)-2-furanphosphonate | HCID 22349233 | — |
Reaction Steps
A mixture of diethyl 5-iodo-2-furanphosphonate (1 mmol), 4-fluorophenylboronic acid (2 mmol), diisopropylethylamine (DIEA) (4 mmol) and bis(acetonitrile)dichloropalladium(II) (0.05 mmol) in 6 mL DMF was heated at 75° C. for 16 h. Extraction and chromatography provided diethyl 5-(4-fluorophenyl)-2-furanphosphonate as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07563774B2 |
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| Source dataset | uspto-grants-2009_07 |
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| ORD ID | ord-d5049d1cc90a43e491ff842861e10a18 |
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| Source note | uspto-grants-2009_07 |
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