3,3-Dimethyl-1-butanol → 3,3-Dimethyl-1-butyl 5-amino-4-oxopentanoate Hydrochloride

Reaction equation

[CH3:1][C:2]([CH3:7])([CH3:6])[CH2:3][CH2:4][OH:5].[ClH:8].[NH2:9][CH2:10][C:11](=[O:17])[CH2:12][CH2:13][C:14](O)=[O:15]>>[ClH:8].[NH2:9][CH2:10][C:11](=[O:17])[CH2:12][CH2:13][C:14]([O:5][CH2:4][CH2:3][C:2]([CH3:7])([CH3:6])[CH3:1])=[O:15]

Participants

Reactant 2

HCID 122333,3-Dimethyl-1-butanol

HCID 123608Aminolevulinic Acid Hydrochloride

Product 1

HCID 574382533,3-Dimethyl-1-butyl 5-amino-4-oxopentanoate Hydrochloride

Procedure

From 3,3-dimethyl-1-butanol (5.0 g; 49 mmol) and 5-amino-4-oxopentanoic acid hydrochloride (1.0 g; 6.0 mmol) at 70° C. The reaction was complete after 4 h. The yield was 0.91 g (60%), mp146-148°.

Workup

customat 70° C

Sources & evidence

ORD record: ord-81830e3d96334285927ebb672f08ddcc
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07563819B1

Reaction notes

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