1-Benzylpiperazine → 1-(2-Phenoxy-2-methylpropionyl)-4-benzylpiperazine

HRID 2294882Notes

Reaction equation

HRID 2294882 reaction equation
[O:1]([C:8]([CH3:13])([CH3:12])[C:9](Cl)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(Cl)Cl>[O:1]([C:8]([CH3:13])([CH3:12])[C:9]([N:24]1[CH2:25][CH2:26][N:21]([CH2:14][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:22][CH2:23]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 759941-BenzylpiperazineHCID 131111912-Methyl-2-phenoxypropanoyl chloride

Product 1

HCID 106169921-(2-Phenoxy-2-methylpropionyl)-4-benzylpiperazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 0.01 mol of 2-phenoxyisobutyric acid chloride (obtained by reaction of thionyl chloride with 2-phenoxyisobutyric acid) in 100 ml of methylene chloride is introduced into an Erlenmeyer flask containing a solution of 0.01 mol of 1-benzylpiperazine in 100 ml of methylene chloride. The mixture is stirred for 5 hours at room temperature, filtered and evaporated to dryness. The residue is taken up in water, basified and extracted with chloroform. The organic phases are combined, dried and evaporated.

Workup

  1. filtrationfiltered
  2. customevaporated to dryness
  3. extractionextracted with chloroform
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-8c2a58b838194708a696d0cbb1851650
Source dataset
uspto-grants-1997_11
Patent number
US05691340

Reaction notes

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