Morpholine → 5-(Morpholine-4-carbonyl)-2-pyridinecarboxylic acid, methyl ester

Reaction equation

[C:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9](Cl)=[O:10])=[CH:7][N:6]=1)([O:3][CH3:4])=[O:2].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[N:14]1([C:9]([C:8]2[CH:12]=[CH:13][C:5]([C:1]([O:3][CH3:4])=[O:2])=[N:6][CH:7]=2)=[O:10])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

Participants

Reactant 2

HCID 8083Morpholine

HCID 151211775-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester

Product 1

HCID 206223075-(Morpholine-4-carbonyl)-2-pyridinecarboxylic acid, methyl ester

Procedure

In step B, the acid chloride (2) is amidated with morpholine by techniques and procedures well known and appreciated by one of ordinary skill in the art to provide the corresponding 5-(morpholine-4-carbonyl)-2-pyridinecarboxylic acid, methyl ester (3).

Sources & evidence

ORD record: ord-a4d0ad80d3014d3581898ee06e834c18
Source dataset: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05691368

Reaction notes

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