Ammonia → Aklomide

HRID 2295370

Reaction equation

HRID 2295370 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[NH3:14]>>[Cl:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:14])=[O:5]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 81522Benzoyl chloride, 2-chloro-4-nitro-

Product 1

HCID 2075AklomideYield 90%

Procedure

Thereafter, 2-chloro-4-nitrobenzoyl chloride (450 g, 2.1 m) was added dropwise to a stirred 28% ammonia solution (2,000 ml) at below room temperature between 9° and 16° C. The precipitated reaction mixture was washed with water and 30% methanol and then vacuum-dried to yield 2-chloro-4-nitrobenzamide (379 g, 90%, mp 168°-170° C.).

Workup

  1. customThe precipitated reaction mixture
  2. washwas washed with water and 30% methanol
  3. customvacuum-dried

Sources & evidence

ORD record
ord-9cec857d21fd40069e2cb33d97c7ca65
Source dataset
uspto-grants-1984_01
Patent number
US04424371

Linked notes

Loading…