HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(Cyclohexylmethyl)piperazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Piperazinecarboxaldehyde | HCID 82191 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1-Formyl-4-cyclohexylmethylpiperazine | HCID 22591423 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(Cyclohexylmethyl)piperazine hydrochloride | HCID 22591386 | — |
Reaction Steps
Sodium triacetoxyborohydride (10.51 g) was added to a methylene chloride (50 ml) solution containing N-formylpiperazine (5.08 g) and cyclohexanecarboxyaldehyde (7.50 g) under ice-cooling, and the mixture was stirred at room temperature for 18 hours to undergo reaction, thereby obtaining 1-formyl-4-cyclohexylmethylpiperazine, which was then acid-treated with hydrochloric acid to obtain 1-(cyclohexylmethyl)piperazine.hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06849622B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-297bfe60233642e4b473882bdbf3e196 |
| Source note | uspto-grants-2005_02 |